Process for preparing 4-substituted imidazole compounds

Details Process for preparing 4-substituted imidazole compounds Process for preparing 4-substituted imidazole compounds

C - Chemistry, Metallurgy

07

D

260/305, 260/314

C07D 233/54 (2006.01) C07D 233/84 (2006.01) C07D 233/88 (2006.01) C07D 403/06 (2006.01) C07F 9/6506 (2006.01)

Patent

CA 1084052

ABSTRACT OF THE DISCLOSURE A process for preparing 4-(oxy, thio or amino)methyl- imidazole compounds via displacement of the trisubstituted phosphonium group from 4-(trisubstituted phosphonium)- methylimidazole compounds is disclosed. The process provides an efficient and high yield method of producing these imidazoles which are useful as intermediates in the preparation of pharmacologically active compounds such as histamine H2-antagonists.

276559

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