Process for preparing 5-(1,3-oxazol-2-yl) benzoic acid...

Details Process for preparing 5-(1,3-oxazol-2-yl) benzoic acid... Process for preparing 5-(1,3-oxazol-2-yl) benzoic acid...

C - Chemistry, Metallurgy

07

D

C07D 263/32 (2006.01)

Patent

CA 2489988

Disclosed are compounds of formula III and a process to prepare a compound of formula III wherein R1, R2, R3 and R6 are defined herein, using a zinc chloride/optionally substituted oxazole adduct and an compound of formula I. Further disclosed are methods of using compounds of formula III to prepare compounds useful in the treatment of Alzheimer's disease and related conditions.

L'invention concerne des composés de formule (III) ainsi qu'un procédé de préparation d'un composé de formule (III), dans laquelle R¿1?, R¿2?, R¿3? et R¿6? sont tels que définis dans la description, en utilisant un adduit de chlorure de zinc / oxazole éventuellement substitué, et un composé de formule (I). L'invention concerne en outre des procédés d'utilisation de composés de formule (III) destinés à préparer des composés utilisés pour le traitement de la maladie d'Alzheimer et d'états apparentés.

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