Process for preparing 5-cyano¬3,4'-bipyridin|-6(1h)-one,...

Details Process for preparing 5-cyano¬3,4'-bipyridin|-6(1h)-one,... Process for preparing 5-cyano¬3,4'-bipyridin|-6(1h)-one,...

C - Chemistry, Metallurgy

07

D

260/279.4

C07D 401/04 (2006.01) C07D 213/38 (2006.01) C07D 213/84 (2006.01)

Patent

CA 1128518

D.N. 3686 ABSTRACT OF THE DISCLOSURE The process which comprises reacting 4-picoline below about 30°C. with at least three mole equivalents of an inorganic acid halide, preferably phosphorus oxychloride, per mole of 4-picoline and excess dimethylformamide, reacting in solution the unisolated resulting N-[3-dimethylamino-2- (4-pyridinyl)-2-propenylidene[-N-methylmethaniminium salt (after adding the reaction mixture to cold water, adjusting the pH to about 8.0 and filtering off the precipitated inorganic cationic salts) with excess .alpha.-cyanoacetamide and at least three mole equivalents of base, and then isolating 5-cyano-[3,4'-bipyridin]-6(lH)-one in free base form (after neutralization) or in the form of its inorganic cationic salt. Said 5-cyano-[3,4'-bipyridin]-6(lH)-one is an inter- mediate for preparing the cardiotonic amrinone.

371706

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