Process for preparing 5-fluoro-2-methyl-1-indanone

Details Process for preparing 5-fluoro-2-methyl-1-indanone Process for preparing 5-fluoro-2-methyl-1-indanone

C - Chemistry, Metallurgy

07

C

260/453, 260/579

C07C 49/76 (2006.01) C07C 97/10 (1980.01)

Patent

CA 1059528

ABSTRACT OF THE DISCLOSURE The invention relates to a novel process for preparing 5-fluoro-2-methyl-1-indanone by reacting under Friedel Crafts conditions fluorobenzene with a novel acid halide of the formula: Image wherein A is methyl or together with G forms methylidene; B is hydrogen, methyl or halo (Cl. Br. F. I); G is methyl. CH2R or together with A forms methylidene, wherein R is halo. hydroxy or -N-(C1-5 alkyl)2; Z is halo; and (1) when A and G together is methylidene. B is methyl; (2) when A and G are each methyl, B is halo; and (3) when A is methyl and B is hydrogen, G is CH2R. The 5-fluoro-2-methyl-1-indanone obtained is a useful intermediate in the preparation of 5-fluoro-2-methyl-1-(p- methylsulfinylbenzylidene)-indene-3-acetic acid which is known to possess anti-inflammatory activity.

296336

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