Process for preparing 6,6-dialkoxy-5-hydroxy-3-oxohexanoic...

Details Process for preparing 6,6-dialkoxy-5-hydroxy-3-oxohexanoic... Process for preparing 6,6-dialkoxy-5-hydroxy-3-oxohexanoic...

C - Chemistry, Metallurgy

07

C

C07C 67/343 (2006.01) C07C 69/716 (2006.01)

Patent

CA 2345134

The invention relates to a method for producing 6,6-dialkoxy-5-hydroxy-3-oxo- hexanoic acid esters of general formula (I), wherein the di-anion of an acetoacetic acid alkyl ester is reacted with an aldehyde. The 6,6-dialkoxy-5- hydroxy-3-oxo-hexanoic acid esters of general formula (I) are important synthesis building blocks for producing HMG-CoA-reductase-inhibitors.

L'invention concerne un procédé de production d'esters d'acide 6,6-dialcoxy-5-hydroxy-3-oxocaproïque correspondant à la formule générale (I), procédé selon lequel on fait réagir le di-anion d'un alkyle ester d'acide acétique avec un aldéhyde. Les esters d'acide 6,6-dialcoxy-5-hydroxy-oxocaproïque correspondant à la formule (I) constituent des éléments de synthèse importants pour la production d'inhibiteurs de la HMG-CoA-réductase.

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