Process for preparing 6-(lower alkoxy)-5-...

Details Process for preparing 6-(lower alkoxy)-5-... Process for preparing 6-(lower alkoxy)-5-...

C - Chemistry, Metallurgy

07

C

260/566.1, 260/6

C07C 49/733 (2006.01) C07C 17/26 (2006.01) C07C 29/58 (2006.01) C07C 37/06 (2006.01) C07C 43/225 (2006.01) C07C 45/00 (2006.01) C07C 45/42 (2006.01) C07C 47/575 (2006.01) C07C 49/223 (2006.01) C07C 65/24 (2006.01)

Patent

CA 1208237

-22- ABSTRACT OF THE DISCLOSURE A process and intermediates for preparing 6-(lower alkoxy)-5-(trifluoro- methyl)-1-naphthalenecarboxylic acid derivatives are disclosed. The derivatives are useful for preparing aldose reductase inhibitors. With reference to the pro- cess, 1,1,1-trifluoro-5-(2-methylphenyl)2,3-pentadione 3-oxime is cyclized to give a key intermediate 3,4-dihydro-1-hydroxy-5-methyl-1-(trifluoromethyl)2(1H)- naphthalenone oxime; and 3,4-dihydro-1-hydroxy-5-methyl-1-(trifluoromethyl)- 2(1H)-naphthalenone is aromatized to 5-methyl-1-(trifluoromethyl)-2-naphthalenol with a dehydrating agent.

413919

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