Process for preparing 7-(2-aminoethyl)-1,3-benzthia- or...

Details Process for preparing 7-(2-aminoethyl)-1,3-benzthia- or... Process for preparing 7-(2-aminoethyl)-1,3-benzthia- or...

C - Chemistry, Metallurgy

07

D

260/311.1, 260/3

C07D 263/58 (2006.01) C07D 277/68 (2006.01)

Patent

CA 1248115

ABSTRACT OF THE DISCLOSURE Certain aminoethyl substituted 1,3-benzthiazol and 1,3-benzoxazol-2(3H) ones having the following formula: Image in which: X is -S- or -O-; R1 and R2 are, each, hydrogen, C1-6-alkyl, allyl, benzyl, phenethyl, methoxyphenethyl or hydroxyphenethyl; and R3 and R4 are, each, hydrogen, hydroxy, halo, C1-3-alkyl or C1-3-alkoxy, or a pharmaceutically, acceptable, acid addition salt thereof are prepared either by reacting an appropriate o - aminophenol or thiophenol with phosgene or by similar chemical reactions. These compounds have potent dopaminergic activity which is of use for treating hypertension and angina.

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