C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/519 (2006.01) C07D 239/54 (2006.01)
Patent
CA 2547159
Processes for preparing 10-amino-3-hydroxy-4-oxo-4,6,7,8,9,10- hexahydropyrimido[1,2-a]azepine-2-carboxylates and related compounds are disclosed. The preparation of carboxamide derivatives from these carboxylates is also disclosed. The carboxamides are HIV integrase inhibitors and are useful for treating HIV infection and AIDS.
L'invention concerne des procédés de préparation de 10-amino-3-hydroxy-4-oxo-4,6,7,8,9,10-hexahydropyrimido[1,2-a]azépine-2-carboxylates et de composés connexes. Elle concerne également la préparation de dérivés de carboxamide à partir de ces carboxylates. Les carboxamides, qui sont des inhibiteurs d'intégrase du VIH, sont également utiles pour traiter l'infection par le VIH et le sida.
Askin David
Conlon David
Kohmura Yoshinori
Lee Jaemoon
Pipik Brenda
Banyu Pharmaceutical Co. Ltd.
Gowling Lafleur Henderson Llp
Merck And Co. Inc.
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