C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/54 (2006.01)
Patent
CA 2571592
The present invention relates to a new process for preparing diisopropyl {[1--(hydroxymethyl)-cyclopropyl]oxy}methylphosphonate (2): (see above formula) which is a key intermediate for synthesizing an antiviral (particularly, against hepatitis B virus) nucleoside analogue. The present invention also relates to new intermediates, and a process for preparing the antiviral nucleoside analogue from said compound (2) prepared according to the present invention.
La présente invention concerne un nouveau procédé de préparation de diisopropyl { [l-(hydroxyméthyl)-cyclopropyl]oxy}méthylphosphonate (2), lequel est un intermédiaire principal pour la synthèse d'un analogue nucléosidique antiviral (notamment, contre le virus de l'hépatite B). Cette invention se rapporte également à de nouveaux intermédiaires et à un procédé de préparation de l'analogue nucléosidique antiviral à partir du composé (2) préparé conformément à la présente invention.
Choi Sang-Chul
Joung Won-Kyo
Lee Ki-Kon
Lee Sang-Who
Nam Kun-Hye
Lg Life Sciences Ltd.
Robic
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