Process for preparing...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 501/22 (2006.01) C07D 501/00 (2006.01)

Patent

CA 2387223

7-amino-3-methoxymethyl-3-cephem-4-carboxylic acid of formula (I) can be easily prepared by reacting 7-aminocephalosporanic acid of formula (II) with an azeotropic mixture of trimethyl borate and methanol in the presence of methanesulfonic acid.

Selon l'invention, on peut facilement obtenir de l'acide 7-amino-3-méthoxyméthyl-3-céphèm-4-carboxylique correspondant à la formule (I) en faisant réagir de l'acide 7-aminocéphalosporanique correspondant à la formule (II) avec un mélange azéotrope de borate de triméthyle et de méthanol, en présence d'acide méthanesulfonique.

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