Process for preparing...

Details Process for preparing... Process for preparing...

C - Chemistry, Metallurgy

07

D

C07D 215/26 (2006.01)

Patent

CA 2517033

A process for preparing 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy- ethyl]-8-hydroxy-(1H)-quinolin-2-one salt. The process involves forming an acid salt of 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8- substituted oxy-(1 H)-quinolin-2-one (V); and converting the acid salt to a salt of 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-(1H)- quinolin-2-one (VI) without isolating the free base of 5-[(R)-2-(5,6-diethyl- indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-(1H)-quinolin-2-one. Formula (A); (V): R = a protecting group, (VI): R = H.

L'invention concerne un procédé pour préparer un sel de 5-[(R)-2-(5,6-diéthyl-indan-2-ylamino)-1-hydroxy-éthyl]-8-hydroxy-(1H)-quinolin-2-one. Le procédé implique la formation d'un sel acide d'oxy-(1H)-quinolin-2-one (V) (V représentant R correspondant à un groupe protecteur) substitué par 5-[(R)-2-(5,6-diéthyl-indan-2-ylamino)-1-hydroxy-éthyl]-8 ; et la conversion dudit sel acide en un sel de 5-[(R)-2-(5,6-diéthyl-indan-2-ylamino)-1-hydroxy-éthyl]-8-hydroxy-(1H)-quinolin-2-one (VI) (VI représentant r correspondant à H), sans isoler la base libre de 5-[(R)-2-(5,6-diéthyl-indan-2-ylamino)-1-hydroxy-éthyl]-8-hydroxy-(1H)-quinolin-2-one.

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