C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/238.6
C07D 281/10 (2006.01)
Patent
CA 2030374
1. "PROCESS FOR PREPARING 2-ARYL-3-HYDROXY-CIS-2,3-DIHYDRO- 1,5-BENZOTHIAZEPIN-4(5H)-ONES AND THEIR DERIVATIVES" Abstract The present invention relates to a novel process for synthetizing 2-aryl-3-hydroxy-cis-2,3-dihydro-1,5-benzo- thiazepin-4(5H)-ones and their derivatives, as optically pure compounds or as their racemic mixtures, having the following general formula (I): Image (I) by using, as synthesis precursors, methyl esters of 2- hydroxy-3-arylthio-3-arylpropionic acids in their threo form, as their hydrochlorides, or as free bases, of general formula (II): Image (II) and treating such precursors with an excess of sodium 2. methoxide, at low temperature, in diethyleneglycol, dimethylether, dimethylformamide and ethyl acetate.
Marchioro Gaetano
Rizzi Amleto
F. I. S. - Fabbrica Italiana Sintetici S.p.a.
Marchioro Gaetano
Rizzi Amleto
Swabey Ogilvy Renault
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