Process for preparing a 1,4-dihydropyridine derivative

Details Process for preparing a 1,4-dihydropyridine derivative Process for preparing a 1,4-dihydropyridine derivative

C - Chemistry, Metallurgy

07

D

260/294.2

C07D 211/90 (2006.01)

Patent

CA 1185243

A b s t r a c t In the process for preparing 4-(2'-nitrophenyl-2,6-dimethyl)-3,5-dicarbmethoxy- 1,4-dihydropyridine of the formula Image 2-nitrobenzaldehyde-diacetate, methyl acetoacetate and ammonia are reacted in the presence of an inert organic solvent, such as methanol, and in the presence or absence of an organic base, such as pyridine, at a temperature of between 20° and 150°C. The compound is a valuable medicine for the treatment of angina pectoris.

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