C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/315.25
C07D 233/60 (2006.01) C07C 62/32 (2006.01) C07C 62/34 (2006.01) C07D 521/00 (2006.01) C07F 7/18 (2006.01)
Patent
CA 1305710
ABSTRACT OF THE DISCLOSURE: A process for preparing a 2,3-dihydro-1H- imidazolylethoxyindene derivative and its pharmaceutically acceptable salts comprises eight steps. 5-methoxy-1- indanone, used as a starting compound, is converted to its corresponding cyanohydrine, followed by treatment with stannous chloride to give 2,3-dihydro-5-methoxy-1H-indene-1- carboxylic acid. Subsequent demethylation of the methoxy group and protection of the carboxylic acid group by esterification precedes formation of the corresponding 2- chloroethyl ether. Lastly, reaction with imidazole and final hydrolysis yields (2,3-dihydro-5-[.beta.-(1H-imidazol-1-yl) ethoxy]-1H-indene-1-carboxylic acid. The process produces intermediates of high purity resulting in an elevated yield of end product. The derivatives produced by the above process are useful antithrombotic agents.
556216
Castello Josep M.
Foguet Rafael
Forne Ernesto
Ortiz Jose A.
Sacristan Aurelio
Ferrer Internacional S.a.
Robic
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