Process for preparing a concentrate of blood coagulation...

Details Process for preparing a concentrate of blood coagulation... Process for preparing a concentrate of blood coagulation...

C - Chemistry, Metallurgy

12

N

195/78, 530/15.0

C12N 9/48 (2006.01) A61K 38/37 (2006.01) C07K 1/36 (2006.01) C07K 14/755 (2006.01)

Patent

CA 2024667

The invention relates to a process far preparing a concentrate of Factor VIII-von Willebrand factor complex having high specific activity from total (non-cryoprecipitated) plasma. The process comprises pre-purifying by means of a double treatment with barium chloride and with aluminium hydroxide. The process then comprises purification by chromatography on an anion exchange resin, of the DEAE-Fractogel type. The process includes a step of viral inactivation by means of a treatment with solvent-detergent. The process also makes it possible to recover fibrinogen, albumin, immunoglobulins, antithrombin III, fibronectin and prothrombin complex, from the same plasma. The different concentrates obtained using the process according to the invention are intended, in particular, for therapeutic use.

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