C - Chemistry – Metallurgy – 08 – B
Patent
C - Chemistry, Metallurgy
08
B
167/169, 167/322
C08B 15/02 (2006.01) A61K 47/38 (2006.01) A61L 15/28 (2006.01) A61L 15/42 (2006.01) A61L 31/04 (2006.01)
Patent
CA 2033046
Oxidized cellulose material is neutralized, by contacting an acidic oxidized cellulose material with a water and alcohol solution of a basic salt of a weak organic acid, e.g. sodium acetate, to elevate the pH of the cellulosic material to between 5 and 8. The resulting neutralized product is storage stable and has therapeutic applications, including hemostasis and adhesion prevention. Furthermore, the neutralized product may be impregnated with acid-sensitive hemostatic agents, such as thrombin, to enhance its hemostatic properties, or with acid-sensitive adhesion-preventive agents, such as t-PA, to enhance its adhesion-prevention properties.
Kamp Lola
Linsky Cary
Saferstein Lowell
Wiseman David
Wolf Stephen
Johnson & Johnson Medical Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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