Process for preparing a pure polymorphic form of...

C - Chemistry – Metallurgy – 07 – F

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C07F 9/38 (2006.01)

Patent

CA 2590046

This process in general relates to the novel process for preparing polymorphic forms of 3-pyridyl-l-hydroxyethylidine-1,1-bisphosphonic acid sodium salt (Risedronate Sodium) in particular risedronate Form A and B employing a solvent system in an appropriate ratio. An improved process for preparation of risedronic acid is also disclosed in the present invention.

La présente invention décrit un nouveau procédé de synthèse de formes polymorphiques du 3-pyridyl-1-hydroxyéthylidine-1,1-bisphosphonate de sodium (Risedronate Sodium), en particulier des Formes A et B du risedronate. Ledit procédé emploie un système de solvants de composition choisie. La présente invention décrit également l~amélioration d~un procédé de synthèse de l~acide risedronique.

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