A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/728 (2006.01) A61K 9/00 (2006.01) A61K 9/08 (2006.01) A61K 47/36 (2006.01) C08B 37/00 (2006.01) C08B 37/08 (2006.01)
Patent
CA 2492739
A process for preparing a sterile ready-to-use aqueous pharmaceutical formulation comprises a high molecular weight hyaluronic acid salt (HA) at a specified concentration, comprising the steps of: providing an aqueous formulation comprising high molecular weight HAat a concentration of less than the specified final concentration; passing said aqueous formulation through a filter having a pore sizeless than 0.45 pm; concentrating said aqueous formulation by applying a vacuum and boiling off water until said specified concentration is reached.
L'invention concerne un procédé permettant de préparer une formulation pharmaceutique aqueuse stérile prête à l'emploi comprenant un sel d'acide hyaluronique (HA) de poids moléculaire élevé, à une concentration élevée, qui comprend les étapes suivantes : fournir une formulation aqueuse comprenant du sel de poids moléculaire élevé, à une concentration inférieure à la concentration finale spécifiée; faire passer la formulation aqueuse à travers un filtre ayant des pores de dimension inférieure à 0,45 µm; concentrer ladite formulation aqueuse par application de vide et par extraction d'eau, jusqu'à ce que ladite concentration spécifiée soit atteinte.
Laboratoire Medidom S.a.
Stikeman Elliott S.e.n.c.r.l.,srl/llp
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