C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
260/316, 260/329
C07C 59/66 (2006.01) C07C 51/00 (2006.01) C07D 333/24 (2006.01)
Patent
CA 1257872
Jean-Daniel ANDRE, Pierre-Jean GROSSI, Alain HEYMES, Giovanni VENERUCCI MANZAROLI PROCESS FOR PREPARING .alpha.-HYDROXY-ALKANOIC ACIDS AND COMPOUNDS OBTAINED BY THIS PROCESS. ABSTRACT OF THE DISCLOSURE The invention relates to a process for preparing .alpha.-hydroxy-alkanoic acids of general formula : Image in which R represents hydrogen or a lower alkyl radical and Cy represents phenyl or a heterocyclic radical, both radicals optionally comprising one or more substituents selected from the group consisting of lower alkyl, lower alkenyl, lower alkynyl radicals and halogen atoms , process which comprises the treatment of an .alpha.,.alpha.-dihalogenated ketone of general formula : Image in which R and Cy have the same meaning as above and X represents chlorine, bromine or iodine, in the presence of an aqueous solution of an alkali metal hydroxide and a non polar organic solvent selected from an aromatic or ali- cyclic hydrocarbon, the treatment being carried out at a temperature between the boiling temperature of the reaction medium at atmospheric pressure and 240°C under pressure and the alkali metal so formed is then acidified to obtain the desired acid.
496430
Andre Jean-Daniel
Grossi Pierre-Jean
Heymes Alain
Venerucci Manzaroli Giovanni
Industria Chimica Produtti Francis S.p.a.
Robic Robic & Associes/associates
Sanofi Industria Chimica Produtti Francis S.p.a.
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