C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/09 (2006.01) C07D 215/22 (2006.01)
Patent
CA 2606675
The present invention relates to a process for isolating (.alpha.S, .beta.R)-6- bromo-.alpha.-[2-(dimethylamino)ethyl]-2-methoxy-.alpha.-1-naphthalenyl-.beta.- phenyl-3-quino lineethano l from a mixture of stereoisomeric forms of 6-bromo- .alpha.-[2-(dimethylamino)ethyl]-2-methoxy-.alpha.-1-naphthalenyl-.beta.- phenyl-3-quino lineethano l by optical resolution with chiral 4- hydroxydinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin 4-oxide or a derivative thereof, in particular (11bR)-4-hydroxydinaphtho[2,1-d:1',2'- f][1,3,2]dioxaphosphepin 4-oxide, as resolution agent.
L'invention concerne un procédé d'isolement de (.alpha.S, ßR)-6-bromo-.alpha.-[2-(diméthylamino)éthyl]-2-méthoxy-.alpha.-1-naphtalényl-ß-phényl-3-quinoline-éthanol à partir d'un mélange de formes de stéréo-isomères de 6-bromo-.alpha.-[2-(diméthylamino)éthyl]-2-méthoxy-.alpha.-1-naphtalényl-ß-phényl-3-quinoline-éthanol, par résolution optique, qui utilise le 4-oxyde de 4-hydroxydinaphto[2,1-d:1',2'-f][1,3,2]dioxaphosphépine chiral ou un dérivé de celui-ci, en particulier le 4-oxyde de (11bR)-4-hydroxydinaphto[2,1-d:1',2'-f][1,3,2]dioxaphosphépine, comme agent de résolution.
Bader Thomas
Horns Stefan
Porstmann Frank Ralf
Gowling Lafleur Henderson Llp
Janssen Pharmaceutica N.v.
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