Process for preparing ampicillin

Details Process for preparing ampicillin Process for preparing ampicillin

C - Chemistry, Metallurgy

07

D

260/114.7

C07D 499/68 (2006.01) C07D 499/00 (2006.01)

Patent

CA 1140115

ABSTRACT OF THE DISCLOSURE A process for preparing ampicillin trihydrate is disclosed which comprises acylating silylated 6-amino- penicillanic acid with D(-)-.alpha.-phenylglycylchloride hydro- chloride directly in the silylation reaction mixture in the presence of urea as an acid acceptor, hydrolyzing the reaction product and precipitating ampicillin-trihydrate from the resulting aqueous solution. The amounts of reactants, in particular of solvents and water, are ad- justed to provide good yields of a product of high purity.

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