Process for preparing an alpha-1-antitrypsin solution

Details Process for preparing an alpha-1-antitrypsin solution Process for preparing an alpha-1-antitrypsin solution

C - Chemistry, Metallurgy

07

K

C07K 14/81 (2006.01) A61L 2/00 (2006.01)

Patent

CA 2534900

A process for preparing A1AT from A1AT-containing solutions, comprising the following steps: (a) subjecting an A1AT-containing solution to ion-exchange chromatography; (b) adding detergents and optionally a solvent for inactivating lipid-enveloped viruses; (c) followed by increasing the salt concentration to salt out the detergents. A1AT having a purity of > 90% with an activity of> 0.8 PEU/mg in its active form.

L'invention concerne un procédé de préparation d'.alpha.-1 antitrypsine provenant de solutions contenant .alpha.-1 antitrypsine. Ledit procédé consiste à (a) soumettre une solution renfermant .alpha.-1 antitrypsine à une chromatographie d'échange ionique, (b) ajouter des détergents et, facultativement, un solvant de façon à inactiver des virus enveloppés de lipides, (c) diminuer ensuite la concentration saline afin d'éliminer le sel des détergents. .alpha.-1 antitrypsine possède une pureté supérieure à 90 % avec une activité supérieure ou égale à 0,8 PEU/mg sous sa forme active.

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