Process for preparing an angiotensin ii receptor antagonist

Details Process for preparing an angiotensin ii receptor antagonist Process for preparing an angiotensin ii receptor antagonist

C - Chemistry, Metallurgy

07

D

C07D 403/10 (2006.01) A61K 31/41 (2006.01) A61P 9/12 (2006.01) C07D 257/04 (2006.01) C07D 487/18 (2006.01)

Patent

CA 2617289

Process for preparing angiotensin II receptor antagonists, in particular irbesartan, protected forms for the preparation thereof, or a pharmaceutically acceptable salt thereof, that comprises the reaction between a biphenylamino derivative and an oxazolone derivative. New intermediates are useful for the preparation of angiotensin II receptor antagonists.

L'invention concerne un procédé de préparation d'antagonistes des récepteurs de l'angiotensine II, en particulier l'irbesartan, des formes protégées destinées à la préparation de ces composés ou un sel pharmaceutiquement acceptable de ceux-ci. Le procédé comporte la mise en réaction d'un dérivé biphénylamino et d'un dérivé d'oxazolone. L'invention concerne aussi de nouveaux produits intermédiaires utiles dans la préparation des antagonistes des récepteurs de l'angiotensine II.

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