Process for preparing an enol silyl ether compound

Details Process for preparing an enol silyl ether compound Process for preparing an enol silyl ether compound

C - Chemistry, Metallurgy

07

F

260/446.6

C07F 7/10 (2006.01) C07F 7/18 (2006.01)

Patent

CA 2025108

A process for preparing an enol silyl ether compound from a diazoacetoacetic acid ester having the general formula (IV): (see formula IV) wherein R1 is a lower alkyl group having 1 to 6 carbon atoms, phenyl group, a substituted phenyl group, an aralkyl group or allyl group, and R2, R3 and R4 are the same or mutually different and each is a lower alkyl group having 1 to 6 carbon atoms, which comprises reacting a diazoacetoacetic acid ester having the general formula (I): (see formula I) wherein R1 is the same as defined above, with a trialkylsilyl chloride having the general formula (II): (see formula II) wherein R2, R3 and R4 are the same as defined above, in an inert solvent in the presence of an organic base and an alkali halide having the general formula (III): MX (III) wherein M is an alkaline metal and X is bromine atom or iodine atom. The desired compound is useful as an intermediate for synthesis of carbapenem .beta.-lactam antibiotics.

Affiliated with

Also associated with

Rating

Process for preparing an enol silyl ether compound does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing an enol silyl ether compound, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing an enol silyl ether compound will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1780868