Process for preparing anti-inflammatory...

Details Process for preparing anti-inflammatory... Process for preparing anti-inflammatory...

C - Chemistry, Metallurgy

07

C

260/515.3

C07C 59/84 (2006.01) C07C 51/347 (2006.01) C07C 51/353 (2006.01)

Patent

CA 1253173

ABSTRACT OF THE DISCLOSURE Cycloalkylidenemethylphenylacetic acid derivatives of formula (I): Image (I) (wherein R1 represents hydrogen or alkyl and n is an integer from 1 to 3) are prepared by reacting a benzaldehyde acid compound of formula (II): Image (II) with an enamine derivative of formula (III): Image (III) (wherein R2 and R3 are various organic groups) and then hydrolizing the product. The use of the acid of formula (II) rather than its corresponding ester enables the reaction to be effected with a good yield and under moderate and economical reaction conditions.

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