Process for preparing benzyl-substituted rhodanine derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 277/14 (2006.01) A61K 31/19 (2006.01) A61K 31/425 (2006.01) C07C 323/56 (2006.01) C07C 323/58 (2006.01)

Patent

CA 2207901

The instant invention provides a novel process for preparing benzyl-substituted rhodanine derivatives. The process is particularly useful for synthesizing the enantiomers of such derivatives. Also provided are novel benzyl-substituted mercaptopropanoic acids and benzyl-substituted thiazolidinones. Such compounds are useful for treating inflammatory bowel disease and, accordingly, the present invention provides a method of treating inflammatory bowel disease in mammals utilizing such novel compounds as well as pharmaceutical compositions containing same.

Nouvelle méthode pour préparer des dérivés de substitution benzyliques de la rhodanine. La méthode est particulièrement utile pour la synthèse d'énantiomères de ces dérivés. Nouveaux dérivés de substitution benzyliques d'acides mercaptopropanoïques et nouveaux dérivés de substitution benzyliques de thiazolidinones. Ces composés sont utiles pour traiter les affections intestinales inflammatoires; la présente invention présente une méthode pour traiter ces affections chez les mammifères à l'aide de ces nouveaux composés, ainsi que des compositions pharmaceutiques qui en renferment.

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