Process for preparing benzylidene derivatives

Details Process for preparing benzylidene derivatives Process for preparing benzylidene derivatives

C - Chemistry, Metallurgy

07

C

260/552, 260/515

C07C 49/84 (2006.01) C07C 45/00 (2006.01) C07C 45/46 (2006.01) C07C 45/54 (2006.01) C07C 45/67 (2006.01) C07C 49/83 (2006.01)

Patent

CA 1119613

ABSTRACT A process for preparing compounds corresponding to the formula (I) (I) Image in which X1, X2, X3 and X4 each represent, independently of one another, a hydrogen or halogen atom or a radical CH3, CH3O, NO2, CF3, C(CH3)3 or CH3CONH, n represents an integer ranging from 1 to 10, n is a radical OH, OM (M = alkali metal), NH2, NH-cycloalkyl, NH-phenyl, NH-benzyl, NH-alkyl, N-(alkyl)2 or N-(alkyl)-(benzyl) and R' represents a hydrogen atom or an alkyl, the alkyls having from 1 to 4 carbon atoms, with the exception of the compounds in which R' = H when X1, X2 and X3 are each, independently of one another, H, Hal, CH3 or CH3O and X4 = H, and with the exception of the compound in which R' = H, X1 = X3 = x4 = H, X2 = 5-Cl, n = 1 and R = OH, which process comprises reacting a ketone of the formula Image (II) with the a compound of the formula NH2-CnH2n-COR (III) in the form of the base or the hydrochloride, and, if desired, then alkylating the resulting compounds (I) in which R' = H, in order to prepare the compounds (I) in which R' = alkyl; or comprises reacting the ketone (II) with a compounds of formula H2N(CH2)nCH.HCl and carrying out a solvolysis the the nitrile (IV) obtained by condensation. The compounds are anti-convulsants and are useful in treating disorders of the central nervous system e.g. epilepsy.

322406

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