Process for preparing biologically active heptapeptides

Details Process for preparing biologically active heptapeptides Process for preparing biologically active heptapeptides

C - Chemistry, Metallurgy

07

K

530/7.06, 167/10

C07K 7/06 (2006.01) A23K 1/16 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1254700

ABSTRACT OF THE DISCLOSURE There is a provided a process for the preparation of peptides of the formula X-Val-Pro-Pro-Leu-Gly-Trp-A-Y wherein x represents a hydrogen atom or a terminal nitrogen protecting group. A represents a neutral L-.alpha.-amino acid residue and Y represents OH, NH2 or a group of the formula OR, NHR, NR2 or NHNHR' wherein R represents a C1-C1 alkyl group optionally substituted, a C7-C14 aralkyl or a phenyl group and R' represents H, any of the groups which R may represent or a protecting group. Preparation of veterinarily acceptable salt of these peptides is also provided, as are preparations of veterinary compositions containing peptides or their salts. The peptides prepared according to the present invention display useful activity on the central nervous system and are active as growth promotors.

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