Process for preparing (bis-(trifluoromethyl)-phenyl)-acetic...

Details Process for preparing (bis-(trifluoromethyl)-phenyl)-acetic... Process for preparing (bis-(trifluoromethyl)-phenyl)-acetic...

C - Chemistry, Metallurgy

07

C

C07C 57/58 (2006.01) C07C 51/353 (2006.01) C07C 51/38 (2006.01) C07C 67/08 (2006.01) C07C 67/32 (2006.01) C07C 67/343 (2006.01) C07C 69/65 (2006.01)

Patent

CA 2315587

[Bis-(trifluoromethyl)-phenyl]-acetic acids are obtained in an advantageous manner by reacting an appropriate bromo- or iodo-bis-{trifluoromethyl)-benzene with a di-C1-C4-alkyl malonate in the presence of a deprotonating agent and a copper salt and hydrolysing and decarboxylating the reaction product in basic medium. It is possible to obtain a mixture of alkyl [bis-(trifluoromethyl)-phenyl]-acetate and alkyl [bis-(tri- fluoromethyl)-phenyl]-malonate by admixing the reaction mixture which is present before hydrolysis and complete decarboxylation with water and acid and heating. From the mixture, it is possible to obtain alkyl [bis-(trifluoromethyl)- phenyl]-acetate by distillation under reduced pressure and dialkyl [bis-(trifluoromethyl)- phenyl]- malonate by work-up by column chromatography, fractional distillation or film distillation. [Bis-(trifluoromethyl)-phenyl]-malonic esters are novel compounds.

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