Process for preparing c-substituted diethylene triamines

Details Process for preparing c-substituted diethylene triamines Process for preparing c-substituted diethylene triamines

C - Chemistry, Metallurgy

07

C

C07C 271/20 (2006.01) C07C 217/62 (2006.01) C07C 269/06 (2006.01) C07C 303/30 (2006.01) C07C 309/66 (2006.01)

Patent

CA 2154558

A process for preparing C-substituted diethylene triamines having general formula (I) is characterized in that a nitrogen-protected aminoethyl alcohol having general formula (II) is reacted with methane sulphonic acid chloride, tosyl chloride or trifluoroacetic acid anhydride in an organic solvent, with addition of a base, to give the corresponding mesylate, tosylate or triflate, is then filtered and the filtrate is reacted with an ethylene diamine having general formula (III) to give the desired nitrogen- protected, carbon-substituted triamine having general formula (I), in which R1 stands for a -(CH2)m-(C6H4)q-(O)k-(CH2)n- (C6H4)l-(O)r-R group or for a -(CH2)m-(C6H10)q-(O)k-(CH2)n- (C6H10)l-(O)r-R group; R2 and R3 each stand for a hydrogen atom or form together a -(CH2)p-alkylene bridge; and R4 stands for an amino protecting group, preferably for a benzyloxycarbonyl group.

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