C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 69/38 (2006.01) C07C 67/03 (2006.01) C07C 67/60 (2006.01) C07D 207/40 (2006.01)
Patent
CA 2652412
The present invention relates to a process for preparing C5 intermediates and their use in the preparation of pyrrole derivatives of a class that is effective at inhibiting the biosynthesis of cholesterol in humans, and more particularly to improved synthetic methods for preparing 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids from 1,4-diketo starting materials. The invention further relates to intermediates in this process.
La présente invention concerne un procédé de préparation d'intermédiaires en C5 et leur utilisation dans la préparation de dérivés de pyrrole d'une classe qui est efficace pour inhiber la biosynthèse du cholestérol chez les êtres humains, et plus particulièrement des procédés de synthèse perfectionnés pour préparer des acides 3,5-dihydroxy-7-pyrrol-1-yl héptanoïques à partir de matières de départ 1,4-dicéto. L'invention porte en outre sur des intermédiaires dans ce procédé.
Bobal Pavel
Borner Armin
Denike Kane
Frantisek Jaroslav
Jeker Nicolas
Goudreau Gage Dubuc
Ratiopharm Gmbh
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