Process for preparing cancer vaccines

Details Process for preparing cancer vaccines Process for preparing cancer vaccines

C - Chemistry, Metallurgy

12

N

C12N 15/87 (2006.01) A61K 39/00 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 14/11 (2006.01) C07K 14/145 (2006.01) C07K 14/485 (2006.01) C07K 14/535 (2006.01) C07K 14/55 (2006.01) C07K 14/57 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12N 7/04 (2006.01) C12Q 1/70 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2158655

Cancer vaccines are prepared by treat- ing tumor cells or fibroblasts with a complex of immunostimulating polypeptide-coding DNA and of DNA-binding substance, for example polylysine, preferably conjugated with transferrine. The complex further contains a conjugate of DNA-binding substance and of an endosomolytic peptide or an adenoviras having at least one E4 defect or one E1a defect associated with other genetic defects.

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