C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
195/131
C12P 13/00 (2006.01) C07B 19/02 (1980.01)
Patent
CA 1146889
CASE 1259 PROCESS FOR PREPARING CARBAMYL DERIVATIVES OF .alpha.-HYDROXY ACIDS AND THE CORRESPONDING d- HYDROXY ACIDS. ABSTRACT This invention relates to a process for preparing carbamyl derivatives of .alpha.-hydroxy acids by the hydrolysis of 5-substi- tuted 2,4-oxazolidinediones. The carbamyl derivatives can be further hydrolysed to .alpha.- hydroxy acids. The invention also relates to a process for the enzymatic hydrolysis of raceme 5-substituted 2,4-oxazolidinediones to give only one of the two possible optical isomers, i.e. the D-carbamyl-.alpha.-hydroxy acid. The free D-.alpha.-hydroxy acid can be obtained from the optically active carbamyl derivative by simple hydrolysis. Of particular interest is the case in which the D-.alpha.-hydroxy acid is D(-)mandelic acid. The enzymatic activity required for preparing the carbamyl derivative of D(-)mandelic acid has been found both in homogen- ised veal liver and in a series of microorganisms, including Agrobacterium radiobacter, Bacillus brevis, Bacillus stearo- thermophilus, Pseudomonas sp., Pseudomonas desmolytica, Pseudomonas fluorescens, Pseudomonas putida.
360509
Centini Felice
Degen Ludwig
Eletti Bianchi Giancarlo
Fascetti Eugenio
Marconi Walter
E.n.i. Ente Nazionale Idrocarburi
Robic Robic & Associes/associates
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