Process for preparing carbapenem compound

Details Process for preparing carbapenem compound Process for preparing carbapenem compound

C - Chemistry, Metallurgy

07

F

C07F 9/6561 (2006.01) C07D 477/04 (2006.01) C07D 477/18 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2145800

The present invention is directed to an effective process for preparing a carbapenem compound of the formula (III): Image (III) wherein R1 and R2 are each H or lower alkyl, R3 is lower alkyl, R4 is a protecting group, L is substituted or unsubstituted arylsulfonyloxy, lower alkanesulfonyloxy, halogeno-lower alkanesulfonyloxy, di-lower alkylphosphoryloxy, etc., and X is H or protected hydroxy, which comprises reacting .beta.-lactam compound (I) with acetic acid ester derivative (II), in the presence of a base, followed by treating the product with an active esterifying agent for hydroxy group. The compounds of the formula (III) are useful as intermediates in the preparation of 1.beta.-alkylcarbapenem compounds having antibacterial activity.

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