Process for preparing carboxamido-4-azasteroids

Details Process for preparing carboxamido-4-azasteroids Process for preparing carboxamido-4-azasteroids

C - Chemistry, Metallurgy

07

J

C07J 73/00 (2006.01) A61K 31/58 (2006.01) C07J 75/00 (2006.01)

Patent

CA 2278487

A process for producing a compound of formula (I) wherein the dotted lines --- independently represent a single or double bond and R, R1, R2 and R3 are each hydrogen or an organic radical, comprises treating the corresponding 17.beta.- carbonylimidazole intermediates with anhydrous acids in the presence of an amine and, optionally, hydrogenating the resulting compound.

Cette invention, qui a trait à un procédé de production d'un composé correspondant à la formule (I) dans laquelle les lignes en pointillés --- représentent, de manière indépendante, une liaison simple ou double et dans laquelle R, R¿1, ?R¿2? et R¿3? représentent, chacun, un hydrogène ou un radical organique, consiste à traiter les intermédiaires 17.beta.-carbonyl-imidazoles correspondants avec des acides anhydres en présence d'une amine et, éventuellement, à hydrogéner le composé résultant.

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