Process for preparing ccr-5 receptor antagonists utilizing...

Details Process for preparing ccr-5 receptor antagonists utilizing... Process for preparing ccr-5 receptor antagonists utilizing...

C - Chemistry, Metallurgy

07

D

C07D 211/98 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2673233

The present invention discloses a novel process to prepare 4-substituted 1-Cyclopropane-sulfonyl-Piperidinyl compounds, which are useful intermediates for the preparation of antagonists of CCR5 receptor and therefore useful for the treatment of HIV virus infected mammals. It specifically discloses a novel process to synthesize 4-[4-[(R)-[1-[cyclopropylsulfonyl)-4-piperidinyl](3-fluorophenyl)methyl]-3(S)-methyl-1-piperazinyl]-1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-methylpiperidine] compounds.

Cette invention se rapporte à un nouveau procédé permettant de préparer des composés 1-cyclopropane-sulfonyl-pipéridinyl substitués en 4, qui sont des intermédiaires utiles dans la préparation d'antagonistes des récepteurs CCR-5 et qui sont donc utiles dans le traitement des mammifères infectés par le virus HIV. L'invention concerne spécifiquement un nouveau procédé permettant de synthétiser les composés 4-[4-[(R)-[1-[cyclopropylsulfonyl)-4-pipéridinyl](3-fluorophényl)méthyl]-3(S)-méthyl-1-pipérazinyl]-1-[(4,6-diméthyl-5-pyrimidinyl)carbonyl]-4-méthylpipéridine].

Affiliated with

Also associated with

Rating

Process for preparing ccr-5 receptor antagonists utilizing... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for preparing ccr-5 receptor antagonists utilizing..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for preparing ccr-5 receptor antagonists utilizing... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1675400