Process for preparing cephalosporin compounds

Details Process for preparing cephalosporin compounds Process for preparing cephalosporin compounds

C - Chemistry, Metallurgy

07

D

260/104.5

C07D 501/36 (2006.01) C07D 501/02 (2006.01) C07D 501/24 (2006.01) A61K 31/545 (2006.01)

Patent

CA 1101840

ABSTRACT OF THE DISCLOSURE A process for preparing a 1,2-propylene glycol solvate com- pound of 7-[D-.alpha.-amino-.alpha.-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol- 5-ylthiomethyl)-3-cephem-4-carboxylic acid which comprises dissolving 7-[D-.alpha.-amino-.alpha.-(p-hydroxyphenyl)-acetamido]-3-(1,2,3- triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid or a solvate compound thereof in an acidic 1,2-propylene glycol under substan- tially anhydrous condition, and neutralizing the resulting solution to precipitate a crystalline 1,2-propylene glycol solvate compound of 7-[D-.alpha.-amino-.alpha.(p-hydroxyphenyl)acetamido]- 3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid.

318788

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