Process for preparing cephalosporin derivatives

Details Process for preparing cephalosporin derivatives Process for preparing cephalosporin derivatives

C - Chemistry, Metallurgy

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C07D 501/04 (2006.01) A61K 31/43 (2006.01) A61K 31/545 (2006.01) C07D 501/16 (2006.01) C07D 501/20 (2006.01) C07D 501/24 (2006.01) C07D 501/32 (2006.01) C07D 501/36 (2006.01) C07D 501/57 (2006.01) C07D 501/60 (2006.01)

Patent

CA 1050531

ABSTRACT 7.alpha.-Methoxycephalosporin derivatives having a 7.beta. substituent of formula R1 - S - A - CO.NH - (in which: R1 represents a hydrogen atom, an acyclic hydro- carbon group, a monocyclic alicyclic hydrocarbon group having a 5- or 6- membered ring, a monocyclic or bicyclic aromatic group, an alkanoyl group, a benzoyl group, or a monocyclic or bicyclic heterocyclic group having at least one ring nitrogen, oxygen or sulphur atom, any of which groups may be substituted or unsubstituted; and A is a straight or branched-chain alkylene group) are prepared by reacting a 7.alpha.-methoxycephalosporin derivative having a 7.beta. substituent of formula X - A - CO.NH - (in which: A is as defined above; and X is a halogen atom) with a thiol compound of formula R1 - SH (I) or with a metal salt thereof.

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