Process for preparing chiral diol sulfones and dihydroxy...

Details Process for preparing chiral diol sulfones and dihydroxy... Process for preparing chiral diol sulfones and dihydroxy...

C - Chemistry, Metallurgy

07

D

C07D 221/06 (2006.01) C07D 221/16 (2006.01) C07D 313/10 (2006.01) C07D 319/06 (2006.01) C07D 337/10 (2006.01) C07D 405/06 (2006.01) C07D 405/12 (2006.01) C07D 409/02 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 487/04 (2006.01) C07D 491/04 (2006.01) C07D 491/044 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2449813

A process is provided for preparing chiral diol sulfones of the structure (I) where R3 is preferably (II) or (III) where R4a is preferably aryl such as phenyl, and R1a is preferably alkyl such as t-butyl, which are intermediates used in preparing HMG CoA reductase inhibitors.

Cette invention concerne un procédé de préparation de sulfones chirals diols représentés par la structure (I), selon laquelle R¿3? est de préférence (II) ou (III), et R¿4? représente de préférence un aryle, tel que phényle, et R¿1a? représente de préférence un alkyle, tel que t-butyl, lesquels sont des intermédiaires utilisés lors de la préparation d'inhibiteurs de l'HMG CoA réductase.

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