C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 221/18 (2006.01) A61K 31/47 (2006.01) C07D 491/04 (2006.01) C07D 491/048 (2006.01) C07D 495/04 (2006.01)
Patent
CA 2195676
A process for preparing a chiral tetracyclic compound of formula (1), wherein R is hydrogen or a C1-C6-alkyl group and Z is oxygen, sulfur or -CH=CH-, the compounds having uses as dopamine agonists. The process involves reacting a chiral starting material and subsequent chiral intermediates in a series of chirality-preserving synthetic reactions.
Procédé de préparation d'un composé tétracyclique chiral de la formule (1), dans laquelle R représente hydrogène ou un groupe alkyle C1-C6 et Z représente oxygène, soufre ou -CH=CH-, ces composés agissant comme agonistes de la dopamine. Ce procédé consiste à faire réagir une matière de départ chirale et des intermédiaires chiraux ultérieurement formés en une série de réactions de synthèse maintenant la chiralité.
Ehrlich Paul P.
Hsaio Chi-Nung
Mclaughlin Maureen A.
Michaelides Michael R.
Abbott Laboratories
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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