Process for preparing cinacalcet hydrochloride

Details Process for preparing cinacalcet hydrochloride Process for preparing cinacalcet hydrochloride

C - Chemistry, Metallurgy

07

C

C07C 209/68 (2006.01) C07C 209/70 (2006.01) C07C 211/62 (2006.01) C07C 221/00 (2006.01) C07C 303/24 (2006.01) C07C 305/18 (2006.01)

Patent

CA 2748595

A process for preparing N-[(11R)-1-(1-naphthyl)ethyl]-3-[3-(trifluoromethyl)- phenyl]propan-1-amine hydrochloride salt of formula (I) i.e. Cinacalcet hydrochloride and its intermediates of formulae (VII) and (VIII) wherein Z is chloride or another pharmaceutically acceptable anionic counterion.

L'invention porte sur un procédé de préparation du sel de chlorhydrate de N-[(11R)-1-(1-naphtyl)éthyl]-3-[3-(trifluorométhyl)-phényl]propan-1-amine de la formule (I), c'est-à-dire du chlorhydrate de cinacalcet et de ses intermédiaires des formules (VII) et (VIII) dans lesquelles Z représente le chlorure ou un autre contre-ion anionique de qualité pharmaceutique.

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