Process for preparing cis-bicyclooctylamines

Details Process for preparing cis-bicyclooctylamines Process for preparing cis-bicyclooctylamines

C - Chemistry, Metallurgy

07

C

260/603.5

C07C 39/30 (2006.01) A61K 31/055 (2006.01) A61K 31/13 (2006.01) A61K 31/135 (2006.01)

Patent

CA 1131253

-1 - PROCESS FOR PREPARING CIS-BICYCLOOCTYLAMINES ABSTRACT OF THE INVENTION A process for preparing antidepressant 2-phenylbicyclooctyl- amines of formula (I) : Image (I) where R1 and R2 represent C1-3 alkyl and Ar represents a phenyl group optionally substituted by up to two halogen atoms, by reduction of a novel enamine intermediate of formula : Image (II) where R3 and R4 are hydrogen or taken together represent a single bond and where X is hydrogen, bromine or chlorine.

331752

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