Process for preparing(+)-cis-sertraline

Details Process for preparing(+)-cis-sertraline Process for preparing(+)-cis-sertraline

C - Chemistry, Metallurgy

07

B

C07B 57/00 (2006.01) C07C 209/52 (2006.01) C07C 211/42 (2006.01)

Patent

CA 2402656

The present invention is directed to (+)-cis-sertraline hydrochloride and methods of preparation. The present invention also includes processes for making sertraline having a cis/trans ratio greater than 3:1, greater than or equal to 8:1, or between about 8:1 and about 12:1, from the Schiff base of sertralone, sertraline-1-imine.

L'invention concerne de l'hydrochlorure de (+)-cis-sertraline et ses procédés de préparation. L'invention porte également sur des procédés de fabrication de sertraline possédant un rapport cis/trans supérieur à 3 :1, supérieur ou égal à 8 :1, ou compris entre environ 8 :1 et 12 :1, à partir de la base de Schiff de sertralone, de sertraline-1-imine.

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