Process for preparing creatine, creatine monohydrate or...

Details Process for preparing creatine, creatine monohydrate or... Process for preparing creatine, creatine monohydrate or...

C - Chemistry, Metallurgy

07

C

C07C 277/00 (2006.01) C07C 227/02 (2006.01) C07C 279/14 (2006.01)

Patent

CA 2648574

A process is proposed for preparing creatine, creatine monohydrate or guanidinoacetic acid, wherein N-methylethanolamine or ethanolamine is first catalytically dehydrogenated, in each case in alkaline solution, and the sarcosinate or glycinate solutions thus obtained are finally reacted under acidic conditions with a guanylating agent, for example O-alkylisourea or cyanamide. In this way, products are obtained in high yields and very good purity, but, in contrast to the prior art, no traces whatsoever of hydrocyanic acid, formaldehyde, chloroacetic acid or ammonia are present. The formation of the toxicologically unsafe dihydrotriazine is also avoided.

L'invention concerne un procédé de fabrication de créatine, de monohydrate de créatine ou d'acide guanidinoacétique, de la N-méthyléthanolamine ou de l'éthanolamine étant tout d'abord déshydrogénée catalytiquement en solution alcaline, puis la solution de sarcosinate ou de glycinate ainsi obtenue étant mise en réaction dans des conditions acides avec un agent de guanylation, tel que par exemple l'O-alkyliso-urée ou le cyanamide. Ce procédé permet d'obtenir des produits avec un rendement élevé et une très grande pureté et, contrairement à l'état de la technique, ne contenant pas de traces d'acide cyanhydrique, de formaldéhyde, d'acide chloroacétique ou d'ammoniac. La formation de dihydrotriazine critique du point de vue toxicologique est également évitée.

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