Process for preparing cyclic thioamides

Details Process for preparing cyclic thioamides Process for preparing cyclic thioamides

C - Chemistry, Metallurgy

07

D

C07D 279/12 (2006.01) C07C 209/50 (2006.01) C07C 211/53 (2006.01) C07C 213/08 (2006.01) C07C 215/16 (2006.01) C07C 231/02 (2006.01) C07C 235/16 (2006.01) C07C 237/04 (2006.01) C07C 319/12 (2006.01) C07C 323/25 (2006.01) C07C 323/52 (2006.01) C07C 323/60 (2006.01) C07D 241/08 (2006.01) C07D 265/32 (2006.01)

Patent

CA 2302727

Disclosed is a process for preparing a compound of the formula: (see formula I) (wherein b is 0, 1, 2 or 3; Y is O, S, NH or N-acetyl; and R3 is halo, cyano, alkyl, alkoxy or CF3), useful for preparing novel aralkyl and aralkylidene heterocyclic lactams and imides which are selective agonists and antagonists of serotonin 1 (5-HT1) receptors. The process involves a reaction of an acid of the formula: (see formula II) with a dehydrating agent.

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