Process for preparing (cycloalkyl)-alkylbenzamides

Details Process for preparing (cycloalkyl)-alkylbenzamides Process for preparing (cycloalkyl)-alkylbenzamides

C - Chemistry, Metallurgy

07

D

260/325.6

C07D 207/08 (2006.01) C07D 207/09 (2006.01)

Patent

CA 1105937

A B S T R A C T A process for preparing benzamides, in the form of racemates or enantiomers, corresponding to the formula (I) Image (I) in which n and m are independently of one another equal to 1, 2, 3 or 4 and R is the radical CF3 or an alkylthio radical in which the alkyl is linear or branched and has from 1 to 6 carbon atoms, and also their addition salts with pharmaceutically acceptable acids, which process comprises reacting a 2-methoxy-5-R-benzoic acid (II) or one of its functionally equivalent derivatives Image (II) with a pyrrolidine, in the form of the racemate or an enantiomer, of the formula (III) Image (III) . The compounds are useful in treating disorders of the central nervous system.

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