Process for preparing cyclobutane purines

Details Process for preparing cyclobutane purines Process for preparing cyclobutane purines

C - Chemistry, Metallurgy

07

D

C07D 473/40 (2006.01) C07D 473/00 (2006.01) C07F 7/10 (2006.01) C07F 9/547 (2006.01) C07H 19/16 (2006.01) C07H 23/00 (2006.01)

Patent

CA 2098033

ABSTRACT Process For Preparing Guanine-Containing Antiviral Agents And Purinyl Salts Useful In Such Process A purine salt of the formula Image wherein Y1 is chloro, bromo, or iodo, and R1, R2, R3, and R4 are independently selected from alkyl and substituted alkyl is reacted with the compound of the formula Z1-X to yield the purine of the formula Image wherein X is a leaving group, and Z1 is a protected form of the carbohydrate surrogate Z. Several routes are disclosed for converting this intermediate to the antiviral agent Image

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