Process for preparing dibenzothiazepine derivatives

Details Process for preparing dibenzothiazepine derivatives Process for preparing dibenzothiazepine derivatives

C - Chemistry, Metallurgy

07

D

C07D 281/16 (2006.01) A61K 31/55 (2006.01) C07B 61/00 (2006.01) C07C 319/14 (2006.01) C07C 323/62 (2006.01)

Patent

CA 2379294

A process for preparing a dibenzothiazepine derivat-ive such as dibenzo[b,f][1,4]thiazepin-11-one employable as a starting material for the preparation of 11-[4-(2- (2-hydroxyethoxy)ethyl)]-1-piperadinyldibenzothiazepine derivative which is known to be effective as an antipsy-chotic pharmaceutical, has the steps of reacting a nitro-benzene derivative with a thiosalicylic acid derivative, reducing the obtained 2-nitro-2'-carboxy-diphenylsulfide derivative, and subjecting the obtained 2-amino-2'- carboxy-diphenylsulfide derivative to dehydration-conden-sation reaction.

L'invention concerne un procédé de production de dérivés de dibenzothiazépine du type dibenzo[b, f] [1, 4]thiazépin-11-one pouvant être utilisés comme produit de départ pour la production de dérivés de 11-[4-(2-(2-hydroxyéthoxy)éthyl)]-1-pipérazinyldibenzothiazépine, que l'on utilise comme médicaments psychotropes. Ledit procédé consiste à faire réagir un dérivé de nitrobenzène avec un dérivé d'acide thiosalicylique ; à réduire le dérivé de 2-nitro-2'-carboxy-diphénylsulfure ainsi obtenu ; puis à déshydrater et à condenser ledit dérivé 2-amino-2'-carboxy-diphénylsulfure.

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