Process for preparing difluorinated diazoniabicycloalkane...

C - Chemistry – Metallurgy – 07 – D

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C07D 487/08 (2006.01) C07B 39/00 (2006.01)

Patent

CA 2137036

The invention is a process for preparing 1,4-diazoniabicycloalkanes of Formula I wherein the corresponding 1-hydro-4-aza-1-azoniabi-cycloalkane salt of the 1,4-diazabicycloalkane is fluorinated in the presence of an alkali metal salt under reaction conditions sufficient to form the desired 1,4-diazoniabicycloalkane. Image 2X- (I) wherein n represents 0, 1 or 2; each R1, R2, R3, R4 and R5 independently represents hydrogen, C1-C6 alkyl, aryl, C1-C6 alkyl-substituted aryl or aryl-substituted C1-C6 alkyl; and each X- represents a counterion or 2X- represents a single divalent counterion.

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