Process for preparing distamycin derivatives

Details Process for preparing distamycin derivatives Process for preparing distamycin derivatives

C - Chemistry, Metallurgy

07

D

C07D 207/34 (2006.01) C07D 207/42 (2006.01)

Patent

CA 2427177

It is described a process for preparing, in high yields and purity and without the need of carrying out several steps and/or isolating many intermediates which could lead to undesired by-products, a distamycin derivative, as reported in the specification. These compounds are useful in therapy as antitumor agents.

La présente invention concerne un procédé permettant de préparer, tel qu'il est décrit dans la spécification, un dérivé de la distamycine avec des rendements élevés et une grande pureté sans qu'il soit nécessaire de procéder en plusieurs étapes et/ou d'isoler de nombreux intermédiaires pouvant entraîner la formation de produits inutiles non désirés. Les composés de l'invention sont utilisés en thérapie comme agents antitumoraux.

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